Now offered at $6,450,000, 5427 Potomac Avenue presents a compelling opportunity to own Washington's most exceptional new residence. The creative vision of District 495, GTM Architects, Studio Sophîste, and Richardson & Associates Landscape Architecture comes together in a custom residence defined by timeless architecture, uncompromising craftsmanship and inspired design. With protected, forever views stretching across the Potomac River valley, this extraordinary home offers uncommon privacy and natural beauty. Only minutes from Georgetown, downtown Washington, neighborhood shopping along MacArthur Boulevard and miles of walking and cycling trails, it delivers a rare luxury: the tranquility of a private retreat without sacrificing the convenience and energy of city living. Four beautifully appointed levels are connected by both an architectural staircase and private elevator. Six bedroom suites, a private library, dedicated wellness studio, dual laundry rooms and gracious formal and informal gathering spaces create a home equally suited to elegant entertaining and everyday living. Expansive Loewen wood windows and French doors frame the home's protected Potomac River valley views and professionally landscaped gardens, filling the interiors with natural light. Whether enjoying morning coffee in the breakfast room, entertaining on the bluestone terraces or gathering in the spectacular Sky Lounge at sunset, the outdoors is never far from view. An exacting standard of quality is evident throughout, from locally crafted custom millwork and seven-inch white oak flooring to natural stone, Waterworks fixtures, Baldwin hardware and TruStile doors. The chef's kitchen features a 48-inch Wolf range, 60-inch Sub-Zero refrigeration, double Cove dishwashers and an expansive butler's pantry with wine column. A custom boot room with integrated command center offers equal parts functionality and elegant transition space. Behind the finishes lies an equally impressive investment in performance: ZIP System construction, extensive waterproofing and sound insulation, five-zone climate control, Energy Recovery Ventilation and advanced technology infrastructure. Prewiring for automated shades, security and expanded audiovisual systems, along with provisions for a golf simulator, theater and future pool, provide exceptional flexibility for the next owner. The upper-level Sky Lounge, complete with a 15-foot bifold window, wet bar and adjoining guest suite, offers panoramic treetop views and an unforgettable setting for entertaining or quiet evenings at home. The lower level adds a wine cellar, guest accommodations, kitchenette and recreation areas, making the home particularly well-suited to accommodate extended family, live-in staff or multigenerational living. From the city's leading independent schools and embassies to Georgetown's restaurants, boutiques and waterfront, Washington's finest destinations are only minutes away.